Albumin-Bound Paclitaxel [Taj Pharma]—Nanoparticle Albumin-Bound, Direct line: +91 8448 444 095
Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others.
Softaxel (paclitaxel and docetaxel) are highly active chemotherapeutic agents in the treatment of breast cancer. Being hydrophobic, Softaxel require solvents (Cremphor EL or polysorbate) to enable parenteral administration. These solvents contribute to the main toxicities seen with Softaxel (hypersensitivity, peripheral neuropathy, and myelo-suppression). Cremophor EL can also leach plasticizers from polyvinyl chloride tubing, which can result in severe, sometimes fatal, anaphylactic reactions. To prevent or limit the onset of hypersensitivity reactions, corticosteroids and antihistamines are standard premedica-tion with Softaxel. Furthermore, Cremophor EL entraps paclitaxel into circulating micelles, which reduces its availability and delivery into tumors [1]. Micelle formation with solvent-based paclitaxel results in nonlinear kinetics and the absence of a dose–response relationship: increasing the dose increases toxicity without an accompanying enhancement in efficacy.
nab-Paclitaxel is a solvent-free, albumin-bound nanoparticle formulation of paclitaxel that takes advantage of the increased delivery of albumin to tumors through receptor-mediated transport called transcytosis. nab-Paclitaxel binds to gp60, the albumin receptor on endothelial cells, which in turn activates caveolin-1 and the formation of caveolae. Caveolae transport the albumin–paclitaxel conjugate to the extracellular space, including the tumor interstitium. In the tumoral interstitium, SPARC (secreted protein, acidic and rich in cysteine) is selectively secreted by the tumors and binds to albumin-bound paclitaxel with the resultant release of paclitaxel in the vicinity of tumor cells. Together the absence of solvents and the receptor-mediated delivery result in decreased toxicity and increased antitumor activity of nab-paclitaxel compared with solvent-based paclitaxel.
nab-Paclitaxel (Softaxel®) has been approved for the treatment of metastatic breast cancer (MBC), based on a phase III trial in 460 patients comparing 260 mg/m2 nab-paclitaxel administered over 30 minutes every 3 weeks (Q3W) without premedication with 175 mg/m2 solvent-based paclitaxel given over 3 hours Q3W with premedication. Overall response rates were 33% and 19% and the median time to progression was 23.0 weeks and 19.6 weeks, respectively. A significant difference was reported in overall survival in patients receiving nab-paclitaxel versus solvent-based paclitaxel in ≥ 2nd lines of treatment (56.4 vs 46.7 weeks, respectively) [3].
Weekly schedules of nab-paclitaxel have proven more effective than Q3W schedules in a randomized phase II study in MBC. Furthermore, outcomes were more favorable for weekly nab-paclitaxel than for 100 mg/m2 docetaxel administered Q3W, with significantly less toxicity [4]. Development of weekly nab-paclitaxel continues in MBC, NSCLC, melanoma, and pancreatic cancer.
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Nanoparticle Albumin-Bound Paclitaxel injection
What is this medicine?
NANOPARTICLE ALBUMIN-BOUND PACLITAXEL (Na no PAHR ti kuhl al BYOO muhn-bound PAK li TAX el) is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat advanced breast cancer, lung cancer, and pancreatic cancer.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Abraxane
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
kidney disease
liver disease
low blood counts, like low white cell, platelet, or red cell counts
lung or breathing disease, like asthma
tingling of the fingers or toes, or other nerve disorder
an unusual or allergic reaction to paclitaxel, albumin, other chemotherapy, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
This drug is given as an infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
What may interact with this medicine?
This medicine may interact with the following medications:
antiviral medicines for hepatitis, HIV or AIDS
certain antibiotics like erythromycin and clarithromycin
certain medicines for fungal infections like ketoconazole and itraconazole
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
gemfibrozil
nefazodone
rifampin
St. John's wort
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.
This medicine can cause serious allergic reactions. If you experience allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, tell your doctor or health care professional right away.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine or for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.
Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.
This medicine may interfere with the ability to get pregnant or to father a child. You should talk to your doctor or health care professional if you are concerned about your fertility.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
changes in vision
fast, irregular heartbeat
low blood pressure
mouth sores
pain, tingling, numbness in the hands or feet
signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
signs of decreased red blood cells - unusually weak or tired, feeling faint or lightheaded, falls
signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
swelling of the ankles, feet, hands
unusually slow heartbeat
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
diarrhea
hair loss
loss of appetite
nausea, vomiting
tiredness
Direct line: +91 8448 444 095
Toll free: 1-800-222-434
Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592
+91 22 2637 4593
Fax No.:+91 22 2634 1274
E-Mail: info@tajpharma.com
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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