Piperacillin (4000mg) + Tazobactum (500mg) (Pipranem - Taj Pharmaceuticals Limited)
Pipranem 4.5 Injection is a combination of two antibiotics. It is used to treat various types of bacterial infections. It fights against the infection by killing the microorganisms.
Pipranem 4.5 Injection is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor’s prescription.
Some of the common side effects of this medicine include nausea, vomiting, diarrhea, and rash. Additionally, you may notice some injection site reactions like pain, swelling, or redness. You should consult your doctor if these side effects do not get better with time and persist for a longer duration.
Before using the medicine, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Your doctor may change the dose or prescribe a different medicine. This medicine is generally considered safe to use during pregnancy and breastfeeding if used under a doctor’s supervision.
USES OF DEPEP INJECTION
Bacterial infections
BENEFITS OF DEPEP INJECTION
In Bacterial infections
Pipranem 4.5 Injection contains two different medicines that work together to kill the bacteria that cause infections. Piperacillin belongs to a group of medicines called penicillins that work by stopping the growth of bacteria. Tazobactam is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Piperacillin against bacteria.
Pipranem 4.5 Injection can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin, teeth, joints, and bones. This medicine usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.
About PIPERACILLIN+TAZOBACTAM
PIPERACILLIN+TAZOBACTAM belongs to the 'Antibiotics' class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.
PIPERACILLIN+TAZOBACTAM contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. In PIPERACILLIN+TAZOBACTAM, Tazobactam works by preventing bacteria from destroying Piperacillin.
PIPERACILLIN+TAZOBACTAM is available in the form of intravenous injection. Like all medicines, PIPERACILLIN+TAZOBACTAM also causes side effects, although not everybody gets them. Common side effects of PIPERACILLIN+TAZOBACTAM include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly.
Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits. Do not use PIPERACILLIN+TAZOBACTAM while having vaccinations with live bacterial vaccines (typhoid vaccine) since PIPERACILLIN+TAZOBACTAM may affect vaccines' activity. PIPERACILLIN+TAZOBACTAM should be used during pregnancy only if the doctor advised you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking PIPERACILLIN+TAZOBACTAM.
Uses of PIPERACILLIN+TAZOBACTAM
Bacterial infections, hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.
Medicinal Benefits
PIPERACILLIN+TAZOBACTAM contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. In PIPERACILLIN+TAZOBACTAM, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, PIPERACILLIN+TAZOBACTAM helps treat various bacterial infections of the stomach, lungs, skin and uterus.
Directions for Use
PIPERACILLIN+TAZOBACTAM is available in the form of intravenous injection. Your doctor will advise the dose and duration based on the severity of your infection. Injection: PIPERACILLIN+TAZOBACTAM is given as an intravenous (into a vein) injection by a doctor or nurse.
Storage
Store in a cool and dry place away from sunlight
Side Effects of PIPERACILLIN+TAZOBACTAM
Nausea
Constipation
Diarrhoea
Headache
Trouble sleeping
In-Depth Precautions and Warning
Drug Warnings
If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases, please inform your doctor before starting PIPERACILLIN+TAZOBACTAM. Please tell your doctor if you are undergoing dialysis treatment since Penicillin antibiotics like Piperacillin are removed by haemodialysis. Your doctor may schedule the dosage after dialysis. Clostridium difficile associated diarrhoea (CDAD) is reported during usage of antibiotics like PIPERACILLIN+TAZOBACTAM. Therefore, please undergo an examination to rule out the chances of CDAD if you experience diarrhoea following PIPERACILLIN+TAZOBACTAM therapy.
Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since PIPERACILLIN+TAZOBACTAM may affect vaccines' activity. PIPERACILLIN+TAZOBACTAM should be used with caution during pregnancy since it crosses the placenta in humans. PIPERACILLIN+TAZOBACTAM is also excreted into breast milk. Please seek medical advice if you are pregnant or breastfeeding before taking PIPERACILLIN+TAZOBACTAM. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Sometimes, antibiotic medications can cause antibiotic resistance. In such cases, your doctor may prescribe other antibiotics, you are not resistant.
Drug Interactions
Drug-Drug Interaction: PIPERACILLIN+TAZOBACTAM may interact with anticoagulants (heparin), anti-cancer drugs (methotrexate), antibiotics (tobramycin, vancomycin), gout medicines (probenecid), and anaesthetic drugs (vecuronium).
Drug-Food Interaction: Avoid alcohol consumption while taking PIPERACILLIN+TAZOBACTAM to prevent unpleasant side-effects, such as nausea and vomiting.
Drug-Disease Interaction: Before taking PIPERACILLIN+TAZOBACTAM, let your doctor know if you have cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and are undergoing dialysis treatment.
Safety Advice
Safety Warning
ALCOHOL
Avoid alcohol consumption while taking PIPERACILLIN+TAZOBACTAM to prevent unpleasant side-effects, such as nausea and vomiting.
Safety Warning
PREGNANCY
PIPERACILLIN+TAZOBACTAM should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking PIPERACILLIN+TAZOBACTAM if you are pregnant or planning to conceive.
Safety Warning
BREAST FEEDING
There is limited data on how PIPERACILLIN+TAZOBACTAM affects breastfed infants. PIPERACILLIN+TAZOBACTAM is excreted into breast milk. Please consult your doctor before taking PIPERACILLIN+TAZOBACTAM if you are breastfeeding.
Safety Warning
DRIVING
It is unknown whether PIPERACILLIN+TAZOBACTAM affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking PIPERACILLIN+TAZOBACTAM, do not drive or operate any machinery.
Safety Warning
LIVER
Let your doctor know if you have any history of liver diseases before taking PIPERACILLIN+TAZOBACTAM. Your doctor will prescribe PIPERACILLIN+TAZOBACTAM only if the benefits outweigh the risk.
Safety Warning
KIDNEY
Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of PIPERACILLIN+TAZOBACTAM may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking PIPERACILLIN+TAZOBACTAM. Your doctor will prescribe PIPERACILLIN+TAZOBACTAM only if the benefits outweigh the risk.
Habit Forming
No
Diet & Lifestyle Advise
Include more fibre enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet.
Eating grapefruit during antibiotics treatment can prevent the body from utilizing PIPERACILLIN+TAZOBACTAM properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic.
Avoid intake of alcoholic beverages with PIPERACILLIN+TAZOBACTAM as it can make you dehydrated and affect your sleep. This can make it more challenging for your body to aid the PIPERACILLIN+TAZOBACTAM in fighting off infections.
Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
Do not walk barefoot at places like gym showers to prevent bacterial infections.
Special Advise
Renal, hepatic, and blood function tests are advised during prolonged therapy to rule out any toxicity caused due to overdose of PIPERACILLIN+TAZOBACTAM.
Clostridium difficile associated diarrhoea (CDAD) is reported during usage of antibiotics like PIPERACILLIN+TAZOBACTAM. Please see your doctor if you experience prolonged diarrhoea.
Penicillin antibiotics are easily removed during dialysis, hence let your doctor know if you are undergoing dialysis treatment so that the dose can be scheduled after the dialysis.
PIPERACILLIN+TAZOBACTAM may also affect urine glucose tests, hence inform your doctor beforehand if you are using PIPERACILLIN+TAZOBACTAM.
Patients Concern
Disease/Condition Glossary
Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria occur in three basic shapes: spherical, rod and spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever and tiredness.
Hospital-acquired pneumonia/ nosocomial pneumonia: It is a lower respiratory infection of the lungs that occurs during a hospital stay.
Ventilator-associated pneumonia: A lung infection occurs in people who are on mechanical ventilation breathing machines in hospitals.
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