What is the role of the antiviral drug remdesivir in the treatment of coronavirus disease 2019 (COVID-19)?

 

What is the role of the antiviral drug remdesivir in the treatment of coronavirus disease 2019 (COVID-19)?


Remdesivir (Veklury) was the first drug approved by the FDA for treating the SARS-CoV-2 virus. It is indicated for treatment of COVID-19 disease in hospitalized adults and children aged 12 years and older who weigh at least 40 kg. The broad-spectrum antiviral is a nucleotide analog prodrug. [21] Full approval was preceded by the US FDA issuing an EUA (emergency use authorization) on May 1, 2020 to allow prescribing remdesivir for severe COVID-19 (confirmed or suspected) in hospitalized adults and children. [155] Upon approval of remdesivir in adults and adolescents, the EUA was updated to maintain the ability for prescribers to treat pediatric patients weighing 3.5 kg to less than 40 kg or children younger than 12 years who weigh at least 3.5 kg.

Reuters exclusively reported that the company was planning to price its version at between 5,000 to 6,000 takas ($59 to $71) per vial.

Remdesivir, intravenously administered in hospitals, is the first treatment to show improvement in COVID-19 trials. It has been approved for emergency use in severely-ill patients in the United States, India and South Korea, and has received full approval in Japan.

Cipla, in an e-mailed statement, did not provide details on when the treatment, called Cipremi, will be available.

Remdesivir has yet to be priced in the United States.

Gilead said on Monday it is targeting remdesivir supply for more than 2 million COVID-19 patients by the end of the year.

The expectations suggest sales of between $2 billion and $3 billion between 2020 and 2021 at a price of $1,000 to $2,000 per course, according to Jefferies analyst Michael Yee.

Cases of the novel coronavirus in India stood at 440,215 on Tuesday, health ministry data (https://www.mohfw.gov.in) showed, while the death toll stood at 14,011. The country is on track to overtake Russia as the third most affected country by cases.














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